Originalarbeiten

Reding T, Palmiere C, Pazhepurackel C, Schiesser M, Bimmler D, Schlegel A, Süss U, Steiner S, Mancina L, Seleznik G, Graf R.
The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII.
Oncotarget, 2017, Vol. 8, (No. 18), pp: 30162-30174.
Impact factor: 5.168

März-Weiss P, Kunz D, Bimmler D, Berkemeier C, Özbek S, Dimitriades-Schmutz B, Haybaeck J, Otten U, Graf R.
Expression of pancreatitis-associated protein after traumatic brain injury: a mechanism potentially contributing to neuroprotection in human brain.
Cellular and Molecular Neurobiology 31 (8):1141-1149, Nov 2011.
Impact factor: 2.293

Li L, Bimmler D, Graf R, Zhou S, Sun Z, Chen J, Siech M, Bachem MG.
PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/TIMP ratio
European Journal of Clinical Investigation 41(2):151-8, 2011 Februar
Impact factor: 3.365

Reding T, Wagner U, Silva AB, Sun L-K, Bain M, Kim S-Y, Bimmler D, R. Graf R.
Inflammation-dependent expression of SPARC during development of chronic pancreatitis in WBN/Kob rats and a microarray gene expression analysis.
Physiol. Genomics 2009;38: 196-204.
Impact factor: 2.806

Li L, Bachem MG, Zhou S, Sun Z, Chen J, Siech M, Bimmler D, Graf R.
Pancreatitis-associated protein inhibits human pancreatic stellate cell MMP-1 and -2, TIMP-1 and -2 secretion and RECK expression.
Pancreatology 2009;9:99-110.
Impact factor: 2.522

Keel M, Harter L, Reding T, Sun LK, Hersberger M, Seifert B, Bimmler D, Graf R.
Pancreatic stone protein is highly increased during posttraumatic sepsis and activates neutrophil granulocytes.
Critical Care Medicine 
2009 May;37(5):1642-8.
Impact factor: 6.283

Sun LK, Reding T, Bain M, Heikenwalder M, Bimmler D, Graf R.
Prostaglandin E2 modulates TNF-alpha-induced MCP-1 synthesis in pancreatic acinar cells in a PKA-dependent manner.
Am J Physiol Gastrointest Liver Physiol. 2007 Dec;293(6):G1196-204.
Impact factor: 3.649

Reding TV, Bimmler D, Perren A, Sun L-K, Fortunato F, Storni F, Graf R.
A Selective COX-2 Inhibitor Suppresses Chronic Pancreatitis in an Animal Model (WBN/Kob rats): Significant Reduction of Macrophage Infiltration and Fibrosis.
Gut 2006 Aug;55(8):1165-73.
Impact factor: 10.732

Fortunato F, Deng X, Gates LK, McClain CJ, Bimmler D, Graf R, Whitcomb DC.
Pancreatic Response to Endotoxin after Chronic Alcohol Exposure: Switch from Apoptosis to Necrosis?
Am J Physiol Gastrointest Liver Physiol 2006 Feb;290(2):G232-41.
Impact factor: 3.649

Bimmler D , Schiesser M, Perren A, Scheele G, Angst E, Meili S, Ammann R, Graf R.
Coordinate Regulation of PSP/reg and PAP Isoforms as a Family of Secretory Stress Proteins in an Animal Model of Chronic Pancreatitis.
Journal of Surgical Research; 2004; 118:122-135.
Impact factor: 2.018

Meili S., Graf R., Perren A., Schiesser M., Bimmler D .
Secretory apparatus assessed by analysis of pancreatic secretory stress protein expression in a rat model of chronic pancreatitis.
Cell & Tissue Research 2003;312:291-299
Impact factor: 3.677

Graf R., Klauser S., Fukuoka S.-I., Schiesser M. and Bimmler D .
The bifunctional rat pancreatic secretory trypsin inhibitor/monitor peptide provides protection against premature activation of pancreatic juice.
Pancreatology 2003;3:195-206
Impact factor: 2.043

Graf R, Schiesser M, Lüssi A, Went Ph, Scheele GA, Bimmler D .
Coordinate Regulation of Secretory Stress Proteins (PSP/reg, PAP I, PAP II, and PAP III) in the Rat Exocrine Pancreas during Experimental Acute Pancreatitis.
Journal of Surgical Research 2002;105:136-144.
Impact factor: 2.018

Zalunardo MP, Bimmler D , Grob UC, Stocker R, Pasch T, Spahn DR.
Late oesophageal perforation following intraoperative transoesophageal echocardiography.
British Journal of Anaesthesia 2002;88:595-597.
Impact factor: 4.237

Graf R, Schiesser M, Bimmler D .
Increased secretion of the pancreatic secretory trypsin inhibitor (PSTI) during development of chronic pancreatitis in the WBN/Kob rat.
Pancreatology 2002;2:108-115.
Impact factor: 2.043

Werder M, Han C, Wehrli E, Bimmler D , Schulthess G, Hauser H.
The role of scavenger receptors SR-BI and CD36 in selective sterol uptake in the small intestine.
Biochemistry 2001;40(38):11643-11650.
Impact factor: 3.377

Graf R, Schiesser M, Scheele GA, Marquardt K, Frick TW, Ammann R, Bimmler D .
A family of 16 kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation.
Journal of Biological Chemistry 2001;276(24):21028-21038.
Impact factor: 4.651

Schiesser M, Bimmler D , Frick TW, Graf R.
Conformational changes of pancreatitis associated protein (PAP) activated by trypsin lead to insoluble protein aggregates.
Pancreas 2001;22(2):186-192.
Impact factor: 2.953

Graf R, Valeri F, Gassmann R, Hailemariam S, Scheele GA, Frick TW, Bimmler D .
Adaptive response of the rat pancreas to dietary substrates: parallel regulation of trypsinogen and pancreatic secretory trypsin inhibitor.
Pancreas 2000;21(2):181-190.
Impact factor: 2.953

Bimmler D , Angst E, Valeri F, Bain M, Scheele GA, Frick TW, Graf R.
Regulation of PSP/reg in rat pancreas: immediate and steady-state adaptation to different diets.
Pancreas 1999;19(3):255-267.
Impact factor: 2.953

Bimmler D , Frick TW, Graf R.
New concepts in understanding the pathophysiology of chronic pancreatitis (letter to the editor)
International Journal of Pancreatology 1999;25:252-253.
Impact factor: 0.924

Bimmler D , Graf R., Frick TW.
Human Lithostathine S2-5: a relevant inhibitor of pancreatic stone formation? (letter to the editor)
Pancreas 1999;18(4):417-418.
Impact factor: 2.953

Frick TW, Fernandez-del Castillo C, Bimmler D , Warshaw AL.
Elevated calcium and activation of trypsinogen in rat pancreatic acini.
Gut 1997;41(3):339-343
Impact factor: 10.732

Bimmler D , Graf R, Scheele GA, Frick TW.
Pancreatic stone protein (lithostathine) - a physiologically relevant pancreatic calcium carbonate crystal inhibitor?
Journal of Biological Chemistry 1997;272(5):3073-3082.
Impact factor: 4.651

Bimmler D , Meyer VE.
Surgical treatment of cubital ulnar nerve entrapment neuropathy: Submuscular anterior transposition or simple decompression of the ulnar nerve? Long-term results in 79 cases.
Ann Chir Main (Ann Hand Surg) 1996;15(3):148-157.
Impact factor: not rated

Bimmler D , Frick, TW, Scheele GA.
High level secretion of native rat pancreatic lithostathine in a baculovirus expression system.
Pancreas 1995;11(1):63-76.
Impact factor: 2.953

Müller MF, Prasad PV, Bimmler D , Kaiser A, Edelman RR.
Functional imaging of the kidney by means of measurement of the apparent diffusion coefficient.
Radiology 1994;193(3):711-715
Impact factor: 6.339

Frick TW, Wiegand D, Bimmler D , Fernandez-del Castillo C, Rattner DW, Warshaw AL.
A rat model to study hypercalcemia-induced pancreatitis.
International Journal of Pancreatology1994;15(2):91-96
Impact factor: 0.924

Weder W, Bimmler D , Schlumpf R, Largiadèr F.
Thorakoskopische Resektion eines Schwannomes.
Helv Chir Acta 1993;60:273-277
Impact factor: 0.047

Candinas D, Decurtins M, Schlumpf R, Bimmler D , Largiadèr F.
Praxis der Nierenentnahme bei Spendern im Kreislaufstillstand.
Helv Chir Acta 1992;59:431-435
Impact factor: 0.047

Bimmler D , von Wartburg U, Frick TW, Meyer VE.
Ergebnisse der operativen Therapie des Sulcus ulnaris Syndromes.
Helv Chir Acta 1992;59:697-700
Impact factor: 0.047

Candinas D, Keusch G, Decurtins M, Bimmler D , Binswanger U, Largiadèr F.
Resultate der Nierentransplantation bei Patienten über dem 60. Lebensjahr.
Helv Chir Acta 1991;58:905-909
Impact factor: 0.047

Übersichtsarbeiten

Graf R. and Bimmler D. 
Biochemistry and Biology of SPINK 
Endocrinology and Metabolism Clinics of North America 2006;35(2):333-343.
Impact factor: 2.375

Graf R,  Schiesser M, Reding Th, Appenzeller Ph, Sun L.-K., Fortunato F., Perren A, Bimmler D. 
Exocrine Meets Endocrine: Pancreatic Stone Protein and Regenerating Protein - Two Sides of the Same Coin.
Journal of Surgical Research, 
2006 Jun 15 ;133(2) :113-20.
Impact factor: 1.726

Bimmler D.
Acute pancreatitis: benefit of early enteral feeding?
In: Falk Symposium 143: Pancreatitis: Advances in Pathobiology, Diagnosis and Treatment.
Edited by: Ammann RW, Büchler MW, Adler G et al.; Springer and Falk Foundation e.V.; 2005

Graf R, Bimmler D , Frick TW, Scheele GA.
Substrate-induced regulation of gene expression in the pancreas.
Yale Journal of Biology and Medicine 1997;70(1):89-95.
Impact factor: 0.381

Frick TW, Speiser DE, Bimmler D , Largiadèr F.
Drug-induced acute pancreatitis; further criticism.
Digestive Diseases 1993;11:113-132
Impact factor: 0.744

Dissertationen

Bimmler Daniel (1992, Universtität Zürich)
Ergebnisse der operativen Therapie des Sulcus ulnaris Syndromes. Submuskuläre Vorverlagerung versus einfache Dekompression des N. ulnaris. 
Leiter: Dr.med. U. Von Wartburg
Referent: Prof. Dr. med. V.E. Meyer

Angst Eliane (1999, Universität Zürich)
Development of a Quantitative Enzyme-linked Immuno-sorbent Assay (ELISA) to Determine the Concentration of Pancreatic Stone Protein in Rat Pancreatic Juice
Leiter: Dr. med. D. Bimmler und Dr. phil. II R. Graf
Referent: Prof. Dr. med. R. Grüssner

Meili Severin (2003, Universität Zürich)
The secretory apparatus assessed by pancreatic secretory stress protein expression in a rat model of chronic pancreatitis.
published in Cell & Tissue Research 2003;312:291-299
Leiter: PD Dr. med. D. Bimmler und PD Dr. phil. II R. Graf
Referent: Prof. Dr. med. P.-A. Clavien

Appenzeller Philippe Enrique (2006, Universität Zürich)
Development of specific ELISAs for the determination of pancreatic secretory stress proteins in the mouse.
Leiter: PD Dr. phil. II Rolf Graf und PD Dr. med. Daniel Bimmler
Referent: Prof. Dr. med. P.-A. Clavien